Jacque Duncan, MD

Professor of Clinical Opthalmology
Ophthalmology
+1 415 514-4241

Retinitis pigmentosa (RP) affects about 1 in 3,500 people worldwide. Age-related macular degeneration (AMD) affects as many as 1 in 4 people by the age of 75 and is the leading cause of blindness in people over age 50 in the United States. Both RP and AMD have a hereditary basis, and currently, there is no cure for either of these types of hereditary retinal degeneration. My clinical specialty is diagnosing and caring for patients with these diseases, using modalities from fluorescein angiography, to optical coherence tomography (OCT), to electroretinography (ERG).

In both RP and AMD, loss of vision is a result of photoreceptor cell degeneration and death. Treatments that can prevent photoreceptor degeneration in experimental models of retinal degenerations may have utility in preventing degeneration in both RP and AMD. I am interested in investigating novel treatments to preserve retinal function in patients with RP, cone rod dystrophy, Stargardt disease, Best disease and AMD.

Patients with rod specific defects undergo degeneration not only of rods, but also of cone photoreceptors. Because cones are responsible for fine visual acuity and color perception, their degeneration is particularly disabling for patients. I am interested in studying the relationship between cone photoreceptor survival and rod-specific gene defects in hereditary retinal degenerations, with the goal of preserving visual function mediated by both rods and cones.

A major challenge in the study of retinal degenerations lies in the fact that the cells affected by these diseases, the photoreceptors and retinal pigment epithelial (RPE) cells, are not visible in the eyes of living people. My collaborator Dr. Austin Roorda at the UC Berkeley School of Optometry has developed a novel device, the adaptive optics scanning laser ophthalmoscope (AOSLO), with the ability to image individual cone photoreceptors in the central retina of living eyes. We have studied cones in patients with RP, cone-rod dystrophy and other types of retinal degeneration to better understand why vision is lost in these diseases. See Dr. Roorda’s laboratory webpage for additional details about this research.

The UCSF Retinal Degenerations Clinic participated in 3 multi-center clinical trials for patients with inherited retinal degenerations. Two Phase II/III clinical trials evaluated the effect that a growth factor called ciliary neurotrophic factor (CNTF) has on retinal function in patients with early and late stages of RP. A Phase I study evaluated the safety and efficacy of a new generation epiretinal prosthetic device to stimulate visual perception in patients with end-stage RP. These clinical trials are among the first to study possible treatments for patients with these blinding diseases.

Publications: 

Natural History of Microperimetry and Optical Coherence Tomography in USH2A-Retinopathy: A Structure-Function Association Study.

American journal of ophthalmology

Vincent A, Liang W, Maguire MG, Duncan JL, Ayala AR, Bernstein PS, Carroll J, Cheetham JK, Durham TA, Farsiu S, Hoyng CB, Huckfeldt RM, Jaffe GJ, Loo J, Pennesi ME, Sahel JA, Singh MS, Zemborain ZZ, Birch DG, Lad EM, Foundation Fighting Blindness Clinical Consortium Investigator Group

Functional Vision Assessment Over 4 Years in USH2A Using the Veteran Affairs Low-Vision Visual Functioning Questionnaire.

Investigative ophthalmology & visual science

Parekh B, Peck-Dimit N, Duncan JL, Samarakoon L, Abalem MF, Andrews CA, Audo I, Ayala AR, Bradley C, Cheetham JK, Dagnelie G, Durham TA, Huckfeldt RM, Lacy GD, Malbin B, Michaelides M, Musch DC, Stingl K, Weng CY, Zmejkoski AZ, Melia M, Jayasundera KT, Foundation Fighting Blindness Clinical Consortium Investigator Group

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases.

Investigative ophthalmology & visual science

Kolawole OU, Bensinger E, Wong J, Rinella N, Foote KG, Zhou H, Wang RK, Duncan JL, Roorda A

Variants in CFAP410 cause a range of retinal and skeletal phenotypes.

NPJ genomic medicine

Schmidt RE, Pohodich AE, Birch D, Jones K, Lam BL, Jung EH, Jain N, Georgiou M, Mahroo OA, Webster AR, Michaelides M, Bakall B, Iannaccone A, Vincent A, Parameswarappa DC, Heon E, Scholl HPN, Janeschitz-Kriegl L, Traboulsi EI, Zein W, Brooks BP, Cukras C, Hufnagel R, Aleman TS, Sylla MM, Tsang SH, Alabek M, Sahel J, Gorin MB, van Genderen MM, Stingl K, Reith M, Kohl S, Amaral RAS, Sallum JMF, Vincent AL, Hull S, Duncan JL, Hanson JVM, Tedeus M, Maggi J, Graf U, Koller S, Berger W, Gerth-Kahlert C, Marra M, Everett LA, Yang P, Pennesi ME

Characterization of Visual Field Loss Over 4 Years in the Rate of Progression in USH2A-Related Retinal Degeneration (RUSH2A) Study.

American journal of ophthalmology

Duncan JL, Maguire MG, McDaniel LS, Doucet NR, Audo I, Ayala AR, Cheetham JK, Cheng P, Durham TA, Huckfeldt RM, Hufnagel RB, Jayasundera KT, Khan N, Malbin B, Maldonado RS, Michaelides M, Pennesi ME, Weng CY, Zmejkoski A, Aravind S, Ishikawa H, Birch DG, Foundation Fighting Blindness Clinical Consortium Investigator Group

Assessing structure - Function relationships in non-neovascular age-related macular degeneration.

Experimental eye research

Chew EY, Cukras C, Duncan JL, Dysli C, He Y, Henry E, Holz F, Moult E, Owsley C, Roorda A, Sarraf D, Schwartz R, Spaide R, Taylor L, Teussink M, Zhang Y, Staurenghi G

Corrigendum to "Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity" [Am J Ophthalmol 2020;219:87-100].

American journal of ophthalmology

Duncan JL, Liang W, Maguire MG, Audo I, Ayala AR, Birch DG, Carroll J, Cheetham JK, Esposti SD, Durham TA, Erker L, Farsiu S, Ferris FL, Heon E, Hufnagel RB, Iannaccone A, Jaffe GJ, Kay CN, Michaelides M, Pennesi ME, Sahel JA, Foundation Fighting Blindness Consortium Investigator Group

Long-term natural history of ellipsoid zone width in USH2A-retinopathy.

The British journal of ophthalmology

Heyang M, Warren JL, Ocieczek P, Duncan JL, Moosajee M, Del Priore LV, Shen LL

Outer retinal reflectivity and visual function loss after anatomically successful macula-off rhegmatogenous retinal detachment repair.

American journal of ophthalmology case reports

Kolli A, Wong J, Duret S, Stewart JM, Connor TB, Roorda A, Carroll J, Duncan JL

Characterizing the Genetic Basis for Inherited Retinal Disease: Lessons Learned From the Foundation Fighting Blindness Clinical Consortium's Gene Poll.

Investigative ophthalmology & visual science

Branham K, Samarakoon L, Audo I, Ayala AR, Cheetham JK, Daiger SP, Dhooge P, Duncan JL, Durham TA, Fahim AT, Huckfeldt RM, Hufnagel RB, Kohl S, Maldonado RS, Melia M, Michaelides M, Pennesi ME, Sahel JA, Sallum JMF, Singh MS, Sharon D, Stepien K, Jones K, Weng CY, Foundation Fighting Blindness Clinical Consortium Investigator Group

De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa.

medRxiv : the preprint server for health sciences

Quinodoz M, Rodenburg K, Cvackova Z, Kaminska K, de Bruijn SE, Iglesias-Romero AB, Boonen EGM, Ullah M, Zomer N, Folcher M, Bijon J, Holtes LK, Tsang SH, Corradi Z, Freund KB, Shliaga S, Panneman DM, Hitti-Malin RJ, Ali M, AlTalbishi A, Andréasson S, Ansari G, Arno G, Astuti GDN, Ayuso C, Ayyagari R, Banfi S, Banin E, Barboni MTS, Bauwens M, Ben-Yosef T, Birch DG, Biswas P, Blanco-Kelly F, Bocquet B, Boon CJF, Branham K, Britten-Jones AC, Bujakowska KM, Cadena EL, Calzetti G, Cancellieri F, Cattaneo L, Issa PC, Chadderton N, Coutinho-Santos L, Daiger SP, De Baere E, de la Cerda B, De Roach JN, De Zaeytijd J, Derks R, Dhaenens CM, Dudakova L, Duncan JL, Farrar GJ, Feltgen N, Fernández-Caballero L, Sallum JMF, Gana S, Garanto A, Gardner JC, Gilissen C, Goto K, Gonzàlez-Duarte R, Griffiths-Jones S, Haack TB, Haer-Wigman L, Hardcastle AJ, Hayashi T, Héon E, Hoischen A, Holtan JP, Hoyng CB, Ibanez MBB, Inglehearn CF, Iwata T, Jones K, Kalatzis V, Kamakari S, Karali M, Kellner U, Knézy K, Klaver CCW, Koenekoop RK, Kohl S, Kominami T, Kühlewein L, Lamey TM, Leroy BP, Martín-Gutiérrez MP, Martins N, Mauring L, Leibu R, Lin S, Liskova P, Lopez I, López-Rodríguez VRJ, Mahroo OA, Manes G, McKibbin M, McLaren TL, Meunier I, Michaelides M, Millán JM, Mizobuchi K, Mukherjee R, Nagy ZZ, Neveling K, Oldak M, Oorsprong M, Pan Y, Papachristou A, Percesepe A, Pfau M, Pierce EA, Place E, Ramesar R, Rasquin FA, Rice GI, Roberts L, Rodríguez-Hidalgo M, Ruiz-Eddera J, Sabir AH, Sajiki AF, Sánchez-Barbero AI, Sarma AS, Sangermano R, Santos CM, Scarpato M, Scholl HPN, Sharon D, Signorini SG, Simonelli F, Sousa AB, Stefaniotou M, Stingl K, Suga A, Sullivan LS, Szabó V, Szaflik JP, Taurina G, Toomes C, Tran VH, Tsilimbaris MK, Tsoka P, Vaclavik V, Vajter M, Valeina S, Valente EM, Valentine C, Valero R, van Aerschot J, van den Born LI, Webster AR, Whelan L, Wissinger B, Yioti GG, Yoshitake K, Zenteno JC, Zeuli R, Zuleger T, Landau C, Jacob AI, Cremers FPM, Lee W, Ellingford JM, Stanek D, Rivolta C, Roosing S

Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs.

Translational vision science & technology

Duncan JL, Bowman A, Laster A, Gelfman C, Birch DG, Boye SE, Daiger SP, Del Priore L, Zack DJ, Handa JT, Foundation Fighting Blindness Scientific Advisory Board

Retinal Disorders.

Cold Spring Harbor perspectives in medicine

Sahel JA, Banin E, Bennett J, Duncan JL, Roska B

Novel BBS1 deletion and BBS9 nonsense pathogenic variant in Bardet-Biedl syndrome.

Ophthalmic genetics

Li JM, Tavares E, Duncan JL, Vincent A, Héon E

Coding and non-coding variants in the ciliopathy gene CFAP410 cause early-onset non-syndromic retinal degeneration.

NPJ genomic medicine

Sangermano R, Gupta P, Price C, Han J, Navarro J, Condroyer C, Place EM, Antonio A, Mukai S, Zanlonghi X, Sahel JA, DiTroia S, O'Heir E, Duncan JL, Pierce EA, Zeitz C, Audo I, Huckfeldt RM, Bujakowska KM

Visual Acuity, Full-field Stimulus Thresholds, and Electroretinography for 4 Years in The Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) Study.

Ophthalmology science

Birch DG, Cheng P, Maguire MG, Duncan JL, Ayala AR, Cheetham JK, Doucet NR, Durham TA, Fahim AT, Ferris FL, Huckfeldt RM, Melia M, Michaelides M, Pennesi ME, Sahel JA, Stingl K, Vincent A, Weng CY

Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study.

Translational vision science & technology

Maguire MG, Birch DG, Duncan JL, Ayala AR, Ayton LN, Cheetham JK, Cheng P, Durham TA, Ferris FL, Hoyng CB, Huckfeldt RM, Jaffe GJ, Kay C, Lad EM, Leroy BP, Liang W, McDaniel LS, Melia M, Michaelides M, Pennesi ME, Sahel JA, Samarakoon L, REDI Working Group and the Foundation Fighting Blindness Clinical Consortium Investigator Group

XOLARIS: A 24-Month, Prospective, Natural History Study of 201 Participants with Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa.

Ophthalmology science

MacLaren RE, Duncan JL, Fischer MD, Lam BL, Meunier I, Pennesi ME, Sankila EK, Gow JA, Li J, Tsang SF, XOLARIS Study Group

Neuropathy target esterase activity defines phenotypes among PNPLA6 disorders.

Brain : a journal of neurology

Liu J, He Y, Lwin C, Han M, Guan B, Naik A, Bender C, Moore N, Huryn LA, Sergeev YV, Qian H, Zeng Y, Dong L, Liu P, Lei J, Haugen CJ, Prasov L, Shi R, Dollfus H, Aristodemou P, Laich Y, Németh AH, Taylor J, Downes S, Krawczynski MR, Meunier I, Strassberg M, Tenney J, Gao J, Shear MA, Moore AT, Duncan JL, Menendez B, Hull S, Vincent AL, Siskind CE, Traboulsi EI, Blackstone C, Sisk RA, Miraldi Utz V, Webster AR, Michaelides M, Arno G, Synofzik M, Hufnagel RB

Perimacular Atrophy Following Voretigene Neparvovec-Rzyl Treatment in the Setting of Previous Contralateral Eye Treatment With a Different Viral Vector.

Translational vision science & technology

Ku CA, Igelman AD, Huang SJ, Bailey ST, Lauer AK, Duncan JL, Weleber RG, Yang P, Pennesi ME

Self-Reported Functional Vision in USH2A-Associated Retinal Degeneration as Measured by the Michigan Retinal Degeneration Questionnaire.

Investigative ophthalmology & visual science

Parekh B, Duncan JL, Samarakoon L, Melia M, Abalem MF, Andrews CA, Audo I, Ayala AR, Bradley C, Cheetham JK, Dagnelie G, Durham TA, Huckfeldt RM, Lacy GD, Malbin B, Michaelides M, Musch DC, Peck-Dimit N, Stingl K, Weng CY, Zmejkoski AZ, Jayasundera KT, Foundation Fighting Blindness Clinical Consortium Investigator Group

Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation.

eLife

Kandoi S, Martinez C, Chen KX, Mehine M, Reddy LVK, Mansfield BC, Duncan JL, Lamba DA

Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation.

eLife

Sangeetha Kandoi, Cassandra Martinez, Kevin Xu Chen, Miika Mehine, L Vinod K Reddy, Brian C Mansfield, Jacque L Duncan, Deepak A Lamba

Differences in COVID-19 Vaccination and Experiences among Patients with Hypertension in Colombia and Jamaica during the COVID-19 Pandemic.

medRxiv : the preprint server for health sciences

Duncan JP, Geng S, Lindsay C, Ferguson T, Mills K, Lopez-Lopez JP, He H, Lanza P, Williams M, Tutse-Tonwe V, Reyes M, Campo A, Marshall A, Lopez-Jaramillo P, Tulloch-Reid MK

Coding and non-coding variants in the ciliopathy gene CFAP410 cause early-onset non-syndromic retinal degeneration.

Research square

Sangermano R, Gupta P, Price C, Han J, Navarro J, Condroyer C, Place EM, Antonio A, Mukai S, Zanlonghi X, Sahel JA, Duncan JL, Pierce EA, Zeitz C, Audo I, Huckfeldt RM, Bujakowska KM

Functional Vision in Patients With Biallelic USH2A Variants.

American journal of ophthalmology

Heon E, Melia M, Bocchino LE, Samarakoon L, Duncan JL, Ayala AR, Audo I, Bradley C, Cheetham JK, Dagnelie G, Durham TA, Hoyng CB, Jain N, Jayasundera KT, Pennesi ME, Weng CY, Foundation Fighting Blindness Consortium Investigator Group

Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation.

medRxiv : the preprint server for health sciences

Kandoi S, Martinez C, Chen K, Mehine M, Mansfield B, Duncan JL, Lamba DA

Classification and Growth Rate of Chorioretinal Atrophy after Voretigene Neparvovec-Rzyl for RPE65-Mediated Retinal Degeneration.

Ophthalmology. Retina

Bommakanti N, Young BK, Sisk RA, Berrocal AM, Duncan JL, Bakall B, Mathias MT, Ahmed I, Chorfi S, Comander J, Nagiel A, Besirli CG

Adaptive Optics Imaging of Inherited Retinal Disease.

Cold Spring Harbor perspectives in medicine

Duncan JL, Carroll J

Enhanced S-Cone Syndrome: Elevated Cone Counts Confer Supernormal Visual Acuity in the S-Cone Pathway.

Investigative ophthalmology & visual science

Wang Y, Wong J, Duncan JL, Roorda A, Tuten WS

Neuropathy target esterase activity predicts retinopathy among PNPLA6 disorders.

bioRxiv : the preprint server for biology

Liu J, He Y, Lwin C, Han M, Guan B, Naik A, Bender C, Moore N, Huryn LA, Sergeev Y, Qian H, Zeng Y, Dong L, Liu P, Lei J, Haugen CJ, Prasov L, Shi R, Dollfus H, Aristodemou P, Laich Y, Németh AH, Taylor J, Downes S, Krawczynski M, Meunier I, Strassberg M, Tenney J, Gao J, Shear MA, Moore AT, Duncan JL, Menendez B, Hull S, Vincent A, Siskind CE, Traboulsi EI, Blackstone C, Sisk R, Utz V, Webster AR, Michaelides M, Arno G, Synofzik M, Hufnagel RB

Change in cone structure over 24 months in USH2A-related retinal degeneration.

American journal of ophthalmology

Duncan JL, Liang W, Maguire MG, Porco TC, Wong J, Audo I, Cava JA, Grieve K, Kalitzeos A, Kreis J, Michaelides M, Norberg N, Paques M, Carroll J, Foundation Fighting Blindness Consortium Investigator Group

Static Perimetry in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) Study: Assessment through Two Years.

American journal of ophthalmology

Duncan JL, Cheng P, Maguire MG, Ayala AA, Birch DG, Cheetham JK, Durham TA, Fahim AT, Hoyng CB, Ishikawa H, Michaelides M, Pennesi ME, Alain-Sahel J, Stingl K, Weng CY, Foundation Fighting Blindness Consortium Investigator Group

Cone structure and function in RPGR- and USH2A-associated retinal degeneration.

American journal of ophthalmology

Micevych PS, Wong J, Zhou H, Wang RK, Porco TC, Carroll J, Roorda A, Duncan JL

Enhanced S-cone Syndrome, a Mini-review.

Advances in experimental medicine and biology

Wang Y, Wong J, Duncan JL, Roorda A, Tuten WS

Retinopathy and optic atrophy in a case of COQ2-related primary coenzyme Q10 deficiency.

Ophthalmic genetics

Stallworth JY, Blair DR, Slavotinek A, Moore AT, Duncan JL, de Alba Campomanes AG

Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.

American journal of ophthalmology

Lad EM, Duncan JL, Liang W, Maguire MG, Ayala AR, Audo I, Birch DG, Carroll J, Cheetham JK, Durham TA, Fahim AT, Loo J, Deng Z, Mukherjee D, Heon E, Hufnagel RB, Guan B, Iannaccone A, Jaffe GJ, Kay CN, Michaelides M, Pennesi ME, Vincent A, Weng CY, Farsiu S, Foundation Fighting Blindness Consortium Investigator Group

Chorioretinal Findings as the Initial Presentation of Chronic Granulomatous Disease.

Ophthalmic surgery, lasers & imaging retina

Chen TA, Rayess N, Afshar AR, Moshfeghi DM, Duncan JL, de Alba Campomanes AG

Expanding the phenotype of TTLL5-associated retinal dystrophy: a case series.

Orphanet journal of rare diseases

Oh JK, Vargas Del Valle JG, Lima de Carvalho JR, Sun YJ, Levi SR, Ryu J, Yang J, Nagasaki T, Emanuelli A, Rasool N, Allikmets R, Sparrow JR, Izquierdo NJ, Duncan JL, Mahajan VB, Tsang SH

Tissue-specific genotype-phenotype correlations among USH2A-related disorders in the RUSH2A study.

Human mutation

Hufnagel RB, Liang W, Duncan JL, Brewer CC, Audo I, Ayala AR, Branham K, Cheetham JK, Daiger SP, Durham TA, Guan B, Heon E, Hoyng CB, Iannaccone A, Kay CN, Michaelides M, Pennesi ME, Singh MS, Ullah E, Foundation Fighting Blindness Consortium Investigator Group

The RUSH2A Study: Dark-Adapted Visual Fields in Patients With Retinal Degeneration Associated With Biallelic Variants in the USH2A Gene.

Investigative ophthalmology & visual science

Birch DG, Samarakoon L, Melia M, Duncan JL, Ayala AR, Audo I, Cheetham JK, Durham TA, Iannaccone A, Pennesi ME, Stingl K, Foundation Fighting Blindness Consortium Investigator Group

Choriocapillaris Changes in Myopic Macular Degeneration.

Translational vision science & technology

Li J, Zhou H, Feinstein M, Wong J, Wang RK, Chan L, Dai Y, Porco T, Duncan JL, Schwartz DM

Comparative Natural History of Visual Function From Patients With Biallelic Variants in BBS1 and BBS10.

Investigative ophthalmology & visual science

Grudzinska Pechhacker MK, Jacobson SG, Drack AV, Scipio MD, Strubbe I, Pfeifer W, Duncan JL, Dollfus H, Goetz N, Muller J, Vincent AL, Aleman TS, Tumber A, Van Cauwenbergh C, De Baere E, Bedoukian E, Leroy BP, Maynes JT, Munier FL, Tavares E, Saleh E, Vincent A, Heon E

Deciphering the genetic architecture and ethnographic distribution of IRD in three ethnic populations by whole genome sequence analysis.

PLoS genetics

Biswas P, Villanueva AL, Soto-Hermida A, Duncan JL, Matsui H, Borooah S, Kurmanov B, Richard G, Khan SY, Branham K, Huang B, Suk J, Bakall B, Goldberg JL, Gabriel L, Khan NW, Raghavendra PB, Zhou J, Devalaraja S, Huynh A, Alapati A, Zawaydeh Q, Weleber RG, Heckenlively JR, Hejtmancik JF, Riazuddin S, Sieving PA, Riazuddin SA, Frazer KA, Ayyagari R

Retinal Degeneration Secondary to MERTK Mutations: Potential Candidate for Gene Therapy.

International Ophthalmology Clinics

Shen-Sampas JH, Duret S, Duncan JL

Correlation Between Localized Choriocapillaris Perfusion and Macular Function in Eyes with Geographic Atrophy: Choriocapillaris Flow Relates to Macular Function in AMD with GA.

American journal of ophthalmology

Rinella NT, Zhou H, Wong J, Zhang Q, Nattagh K, Porco TC, Wang RK, Schwartz DM, Duncan JL

Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A).

American journal of medical genetics. Part A

Iannaccone A, Brewer CC, Cheng P, Duncan JL, Maguire MG, Audo I, Ayala AR, Bernstein PS, Bidelman GM, Cheetham JK, Doty RL, Durham TA, Hufnagel RB, Myers MH, Stingl K, Zein WM, Foundation Fighting Blindness Consortium Investigator Group

PRESUMED FOVEAL BACILLARY LAYER DETACHMENT IN A PATIENT WITH TOXOPLASMOSIS CHORIORETINITIS AND PACHYCHOROID DISEASE.

Retinal cases & brief reports

Mehta N, Chong J, Tsui E, Duncan JL, Curcio CA, Freund KB, Modi Y

Macular Degeneration, Age Related.

Liron Naftali Ben Haim, Jacque L Duncan, Shiri Zayit-Soudry

PHENOTYPIC HETEROGENEITY IN A FAMILY WITH X-LINKED FAMILIAL EXUDATIVE VITREORETINOPATHY WITH PREVENTION OF VISUAL LOSS IN AN AFFECTED MALE CHILD WITH LASER TREATMENT IN INFANCY.

Retinal cases & brief reports

Flores Pimentel MA, De la Huerta I, Duncan JL, Slavotinek AM, Moore AT, de Alba Campomanes AG

Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium.

Translational vision science & technology

Durham TA, Duncan JL, Ayala AR, Birch DG, Cheetham JK, Ferris FL, Hoyng CB, Pennesi ME, Sahel JA, Foundation Fighting Blindness Consortium Investigator Group

SARS-CoV-2: an occupational hazard presenting challenges for low- and middle-income countries.

International archives of occupational and environmental health

Biometrics, Impact, and Significance of Basal Linear Deposit and Subretinal Drusenoid Deposit in Age-Related Macular Degeneration.

Investigative ophthalmology & visual science

Chen L, Messinger JD, Kar D, Duncan JL, Curcio CA

The HIV epidemic in Jamaica: a need to strengthen the National HIV Program.

Revista panamericana de salud publica = Pan American journal of public health

Figueroa JP, Duncan JP, Bailey A, Skyers N

Response to: Comment on: Dark without pressure retinal changes in a paediatric age group.

Eye (London, England)

Pimentel MAF, Duncan JL, de Alba Campomanes AG, Moore AT

The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline.

Translational vision science & technology

Birch DG, Cheng P, Duncan JL, Ayala AR, Maguire MG, Audo I, Cheetham JK, Durham TA, Fahim AT, Ferris FL, Heon E, Huckfeldt RM, Iannaccone A, Khan NW, Lad EM, Michaelides M, Pennesi ME, Stingl K, Vincent A, Weng CY, Foundation Fighting Blindness Consortium Investigator Group

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness.

Human molecular genetics

Slavotinek A, Misceo D, Htun S, Mathisen L, Frengen E, Foreman M, Hurtig JE, Enyenihi L, Sterrett MC, Leung SW, Schneidman-Duhovny D, Estrada-Veras J, Duncan JL, Haaxma CA, Kamsteeg EJ, Xia V, Beleford D, Si Y, Douglas G, Treidene HE, van Hoof A, Fasken MB, Corbett AH

ABUNDANCE AND MULTIMODAL VISIBILITY OF SOFT DRUSEN IN EARLY AGE-RELATED MACULAR DEGENERATION: A Clinicopathologic Correlation.

Retina (Philadelphia, Pa.)

Chen L, Messinger JD, Sloan KR, Wong J, Roorda A, Duncan JL, Curcio CA

Dark without pressure retinal changes in a paediatric age group.

Eye (London, England)

Flores Pimentel MA, Duncan JL, de Alba Campomanes AG, Moore A

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.

Translational vision science & technology

Debra A. Thompson, Alessandro Iannaccone, Robin R. Ali, Vadim Y. Arshavsky, Isabelle Audo, James W. B. Bainbridge, Cagri G. Besirli, David G. Birch, Kari E. Branham, Artur V. Cideciyan, Steven P. Daiger, Deniz Dalkara, Jacque L. Duncan, Abigail T. Fahim, John G. Flannery, Roberto Gattegna, John R. Heckenlively, Elise Heon, K. Thiran Jayasundera, Naheed W. Khan, Henry Klassen, Bart P. Leroy, Robert S. Molday, David C. Musch, Mark E. Pennesi, Simon M. Petersen-Jones, Eric A. Pierce, Rajesh C. Rao, Thomas A. Reh, Jose A. Sahel, Dror Sharon, Paul A. Sieving, Enrica Strettoi, Paul Yang, David N. Zacks

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.

Translational vision science & technology

Thompson DA, Iannaccone A, Ali RR, Arshavsky VY, Audo I, Bainbridge JWB, Besirli CG, Birch DG, Branham KE, Cideciyan AV, Daiger SP, Dalkara D, Duncan JL, Fahim AT, Flannery JG, Gattegna R, Heckenlively JR, Heon E, Jayasundera KT, Khan NW, Klassen H, Leroy BP, Molday RS, Musch DC, Pennesi ME, Petersen-Jones SM, Pierce EA, Rao RC, Reh TA, Sahel JA, Sharon D, Sieving PA, Strettoi E, Yang P, Zacks DN, Monaciano Consortium

OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker.

Translational vision science & technology

Nattagh K, Zhou H, Rinella N, Zhang Q, Dai Y, Foote KG, Keiner C, Deiner M, Duncan JL, Porco TC, Wang RK, Schwartz DM

Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation with Other Measures of Disease Severity.

American journal of ophthalmology

Duncan JL, Liang W, Maguire MG, Audo I, Ayala AR, Birch DG, Carroll J, Cheetham JK, Esposti SD, Durham TA, Erker L, Farsiu S, Ferris FL, Heon E, Hufnagel RB, Iannaccone A, Jaffe GJ, Kay CN, Michaelides M, Pennesi ME, Sahel JA

Comparing Cone Structure and Function in RHO- and RPGR-Associated Retinitis Pigmentosa.

Investigative ophthalmology & visual science

Foote KG, Wong JJ, Boehm AE, Bensinger E, Porco TC, Roorda A, Duncan JL

Automated morphometric measurement of the retinal pigment epithelium complex and choriocapillaris using swept source OCT.

Biomedical optics express

Zhou H, Dai Y, Gregori G, Rosenfeld PR, Duncan JL, Schwartz DM, Wang RK

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations.

Translational vision science & technology

Ian M. MacDonald, Christopher Moen, Jacque L. Duncan, Stephen H. Tsang, Jasmina Cehajic-Kapetanovic, Tomas S. Aleman

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations.

Translational vision science & technology

MacDonald IM, Moen C, Duncan JL, Tsang SH, Cehajic-Kapetanovic J, Aleman TS

CHOROIDEREMIA: Retinal Degeneration With an Unmet Need.

Retina (Philadelphia, Pa.)

Pennesi ME, Birch DG, Duncan JL, Bennett J, Girach A

Cone Structure Persists Beyond Margins of Short-Wavelength Autofluorescence in Choroideremia.

Investigative ophthalmology & visual science

Foote KG, Rinella N, Tang J, Bensaid N, Zhou H, Zhang Q, Wang RK, Porco TC, Roorda A, Duncan JL

Quantifying Choriocapillaris Flow Voids in Patients With Geographic Atrophy Using Swept-Source OCT Angiography.

Ophthalmic surgery, lasers & imaging retina

Rinella NT, Zhou H, Zhang Q, Keiner C, Oldenburg CE, Duncan JL, Wang RK, Schwartz DM

Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography.

Clinical ophthalmology (Auckland, N.Z.)

Keiner CM, Zhou H, Zhang Q, Wang RK, Rinella NT, Oldenburg CE, Duncan JL, Schwartz DM

Influence of eye pigmentation on retinal degeneration in P23H and S334ter mutant rhodopsin transgenic rats.

Experimental eye research

Lowe RJ, Daniello KM, Duncan JL, Yang H, Yasumura D, Matthes MT, LaVail MM

Loss of Foveal Cone Structure Precedes Loss of Visual Acuity in Patients With Rod-Cone Degeneration.

Investigative ophthalmology & visual science

Bensinger E, Rinella N, Saud A, Loumou P, Ratnam K, Griffin S, Qin J, Porco TC, Roorda A, Duncan JL

Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients With Inherited Retinal Degenerations.

Investigative ophthalmology & visual science

Foote KG, De la Huerta I, Gustafson K, Baldwin A, Zayit-Soudry S, Rinella N, Porco TC, Roorda A, Duncan JL

Diagnosis and Complementary Examinations.

Young Ju Lew,Jacque L. Duncan

Dysflective Cones.

Advances in experimental medicine and biology

Duncan JL, Roorda A

Multimodal Imaging in Choroideremia.

Advances in experimental medicine and biology

Foote KG, Roorda A, Duncan JL

OCT Angiography and Cone Photoreceptor Imaging in Geographic Atrophy.

Investigative ophthalmology & visual science

Qin J, Rinella N, Zhang Q, Zhou H, Wong J, Deiner M, Roorda A, Porco TC, Wang RK, Schwartz DM, Duncan JL

Cobalamin D Deficiency Identified Through Newborn Screening.

JIMD reports

Abu-El-Haija A, Mendelsohn BA, Duncan JL, Moore AT, Glenn OA, Weisiger K, Gallagher RC

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps.

Translational vision science & technology

Duncan JL, Pierce EA, Laster AM, Daiger SP, Birch DG, Ash JD, Iannaccone A, Flannery JG, Sahel JA, Zack DJ, Zarbin MA

Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration.

Investigative ophthalmology & visual science

Foote KG, Loumou P, Griffin S, Qin J, Ratnam K, Porco TC, Roorda A, Duncan JL

A mutation in IFT43 causes non-syndromic recessive retinal degeneration.

Human molecular genetics

Biswas P, Duncan JL, Ali M, Matsui H, Naeem MA, Raghavendra PB, Frazer KA, Arts HH, Riazuddin S, Akram J, Hejtmancik JF, Riazuddin SA, Ayyagari R

High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.

American journal of ophthalmology

Lew YJ, Rinella N, Qin J, Chiang J, Moore AT, Porco TC, Roorda A, Duncan JL

Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.

Experimental eye research

LaVail MM, Nishikawa S, Steinberg RH, Naash MI, Duncan JL, Trautmann N, Matthes MT, Yasumura D, Lau-Villacorta C, Chen J, Peterson WM, Yang H, Flannery JG

Whole Genome Sequencing Revealed Mutations in Two Independent Genes as the Underlying Cause of Retinal Degeneration in an Ashkenazi Jewish Pedigree.

Genes

Gustafson K, Duncan JL, Biswas P, Soto-Hermida A, Matsui H, Jakubosky D, Suk J, Telenti A, Frazer KA, Ayyagari R

Report From the NEI/FDA Endpoints Workshop on Age-Related Macular Degeneration and Inherited Retinal Diseases.

Investigative ophthalmology & visual science

Csaky K, Ferris F, Chew EY, Nair P, Cheetham JK, Duncan JL

Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.

Investigative ophthalmology & visual science

Litts KM, Cooper RF, Duncan JL, Carroll J

Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis.

American journal of ophthalmology case reports

Tu JH, Foote KG, Lujan BJ, Ratnam K, Qin J, Gorin MB, Cunningham ET, Tuten WS, Duncan JL, Roorda A

Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.

Ophthalmic genetics

Oatts JT, Duncan JL, Hoyt CS, Slavotinek AM, Moore AT

Genetic analysis of 10 pedigrees with inherited retinal degeneration by exome sequencing and phenotype-genotype association.

Physiological genomics

Biswas P, Duncan JL, Maranhao B, Kozak I, Branham K, Gabriel L, Lin JH, Barteselli G, Navani M, Suk J, Parke M, Schlechter C, Weleber RG, Heckenlively JR, Dagnelie G, Lee P, Riazuddin SA, Ayyagari R

Ocular findings in a patient with fucosidosis.

American journal of ophthalmology case reports

Sánchez LR, Oatts JT, Duncan JL, Packman S, Moore AT

Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus® II retinal prosthesis system.

Clinical & experimental ophthalmology

Dagnelie G, Christopher P, Arditi A, da Cruz L, Duncan JL, Ho AC, Olmos de Koo LC, Sahel JA, Stanga PE, Thumann G, Wang Y, Arsiero M, Dorn JD, Greenberg RJ, Argus® II Study Group

Improvements in vision-related quality of life in blind patients implanted with the Argus II Epiretinal Prosthesis.

Clinical & experimental optometry

Duncan JL, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Ho AC, Olmos de Koo LC, Barale PO, Stanga PE, Thumann G, Wang Y, Greenberg RJ

Long-term Follow-up of Patients With Retinitis Pigmentosa Receiving Intraocular Ciliary Neurotrophic Factor Implants.

American journal of ophthalmology

Birch DG, Bennett LD, Duncan JL, Weleber RG, Pennesi ME

Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial.

Ophthalmology

da Cruz L, Dorn JD, Humayun MS, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan AV, de Juan E, Duncan JL, Eliott D, Fawzi A, Olmos de Koo LC, Ho AC, Brown G, Haller J, Regillo C, Del Priore LV, Arditi A, Greenberg RJ, Argus II Study Group

A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration.

Human molecular genetics

Biswas P, Chavali VR, Agnello G, Stone E, Chakarova C, Duncan JL, Kannabiran C, Homsher M, Bhattacharya SS, Naeem MA, Kimchi A, Sharon D, Iwata T, Riazuddin S, Reddy GB, Hejtmancik JF, Georgiou G, Riazuddin SA, Ayyagari R

Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.

Scientific reports

Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB

An analysis of observer-rated functional vision in patients implanted with the Argus II Retinal Prosthesis System at three years.

Clinical & experimental optometry

Geruschat DR, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Duncan JL, Ho AC, Olmos de Koo LC, Sahel JA, Stanga PE, Thumann G, Wang V, Greenberg RJ

Adaptive optics ophthalmoscopy.

Annual review of vision science

Roorda A, Duncan JL

Repeatability of Cone Spacing Measures in Eyes With Inherited Retinal Degenerations.

Investigative ophthalmology & visual science

Zayit-Soudry S, Sippl-Swezey N, Porco TC, Lynch SK, Syed R, Ratnam K, Menghini M, Roorda AJ, Duncan JL

DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS.

Retina (Philadelphia, Pa.)

Lujan BJ, Roorda A, Croskrey JA, Dubis AM, Cooper RF, Bayabo JK, Duncan JL, Antony BJ, Carroll J

Spontaneous Regeneration of Human Photoreceptor Outer Segments.

Scientific reports

Horton JC, Parker AB, Botelho JV, Duncan JL

Correlation of Serial Scleral and Corneal Pneumatonometry.

Ophthalmology

Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y

Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind.

Ophthalmology

Ho AC, Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan AV, de Juan E, Duncan JL, Eliott D, Fawzi A, Olmos de Koo LC, Brown GC, Haller JA, Regillo CD, Del Priore LV, Arditi A, Geruschat DR, Greenberg RJ, Argus II Study Group

Adaptive optics microperimetry and OCT images show preserved function and recovery of cone visibility in macular telangiectasia type 2 retinal lesions.

Investigative ophthalmology & visual science

Wang Q, Tuten WS, Lujan BJ, Holland J, Bernstein PS, Schwartz SD, Duncan JL, Roorda A

Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects.

Investigative ophthalmology & visual science

Menghini M, Lujan BJ, Zayit-Soudry S, Syed R, Porco TC, Bayabo K, Carroll J, Roorda A, Duncan JL

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

JAMA neurology

Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ

Ocular Phenotype of a Family with FAM161A-associated Retinal Degeneration.

Ophthalmic genetics

Duncan JL, Biswas P, Kozak I, Navani M, Syed R, Soudry S, Menghini M, Caruso RC, Jeffrey BG, Heckenlively JR, Reddy GB, Lee P, Roorda A, Ayyagari R

The reliability of parafoveal cone density measurements.

The British journal of ophthalmology

Liu BS, Tarima S, Visotcky A, Pechauer A, Cooper RF, Landsem L, Wilk MA, Godara P, Makhijani V, Sulai YN, Syed N, Yasumura G, Garg AK, Pennesi ME, Lujan BJ, Dubra A, Duncan JL, Carroll J

Diagnosis and complementary examinations.

Developments in ophthalmology

Menghini M, Duncan JL

Retinal hemangioblastoma.

JAMA ophthalmology

Gorovoy IR, Duncan JL

Mutations in the small nuclear riboprotein 200 kDa gene (SNRNP200) cause 1.6% of autosomal dominant retinitis pigmentosa.

Molecular vision

Bowne SJ, Sullivan LS, Avery CE, Sasser EM, Roorda A, Duncan JL, Wheaton DH, Birch DG, Branham KE, Heckenlively JR, Sieving PA, Daiger SP

Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration.

Investigative ophthalmology & visual science

Zayit-Soudry S, Duncan JL, Syed R, Menghini M, Roorda AJ

Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.

Neurology

Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL

Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations.

Investigative ophthalmology & visual science

Ratnam K, Carroll J, Porco TC, Duncan JL, Roorda A

Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO).

Yuhua Zhang, Christopher Girkin, Jacque Duncan, Austin Roorda

Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa.

American journal of ophthalmology

Birch DG, Weleber RG, Duncan JL, Jaffe GJ, Tao W, Ciliary Neurotrophic Factor Retinitis Pigmentosa Study Groups

High-resolution images of retinal structure in patients with choroideremia.

Investigative ophthalmology & visual science

Syed R, Sundquist SM, Ratnam K, Zayit-Soudry S, Zhang Y, Crawford JB, MacDonald IM, Godara P, Rha J, Carroll J, Roorda A, Stepien KE, Duncan JL

Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 gene.

JAMA ophthalmology

Ratnam K, Västinsalo H, Roorda A, Sankila EM, Duncan JL

Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease.

Investigative ophthalmology & visual science

Branham K, Othman M, Brumm M, Karoukis AJ, Atmaca-Sonmez P, Yashar BM, Schwartz SB, Stover NB, Trzupek K, Wheaton D, Jennings B, Ciccarelli ML, Jayasundera KT, Lewis RA, Birch D, Bennett J, Sieving PA, Andreasson S, Duncan JL, Fishman GA, Iannaccone A, Weleber RG, Jacobson SG, Heckenlively JR, Swaroop A

Identification of a novel mutation in the CDHR1 gene in a family with recessive retinal degeneration.

Archives of ophthalmology (Chicago, Ill. : 1960)

Duncan JL, Roorda A, Navani M, Vishweswaraiah S, Syed R, Soudry S, Ratnam K, Gudiseva HV, Lee P, Gaasterland T, Ayyagari R

Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease.

Investigative ophthalmology & visual science

McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Lowe RJ, Duncan JL, Yang H, Ahern K, Daniello KM, Silver B, LaVail MM

Macular Degeneration, Age Related.

Shiri Zayit-Soudry,Jacque L Duncan

Interim results from the international trial of Second Sight's visual prosthesis.

Ophthalmology

Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan JL, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ

Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 gene.

Investigative ophthalmology & visual science

Duncan JL, Ratnam K, Birch DG, Sundquist SM, Lucero AS, Zhang Y, Meltzer M, Smaoui N, Roorda A

Outer retinal structure in patients with acute zonal occult outer retinopathy.

American journal of ophthalmology

Mkrtchyan M, Lujan BJ, Merino D, Thirkill CE, Roorda A, Duncan JL

Growth Factor Therapy for Retinal Neuroprotection.

Retinal Physician

REEMA SYED,JACQUE L. DUNCAN

Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease.

Investigative ophthalmology & visual science

Chen Y, Ratnam K, Sundquist SM, Lujan B, Ayyagari R, Gudiseva VH, Roorda A, Duncan JL

Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment.

Investigative ophthalmology & visual science

Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Lujan BJ, Tao W, Porco TC, Roorda A, Duncan JL

BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition.

Human mutation

Deveault C, Billingsley G, Duncan JL, Bin J, Theal R, Vincent A, Fieggen KJ, Gerth C, Noordeh N, Traboulsi EI, Fishman GA, Chitayat D, Knueppel T, Millán JM, Munier FL, Kennedy D, Jacobson SG, Innes AM, Mitchell GA, Boycott K, Héon E

Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene.

Investigative ophthalmology & visual science

Duncan JL, Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Day S, Zhang Y, Roorda A

Visual field loss in patients with cytomegalovirus retinitis.

Ophthalmology

Thorne JE, Van Natta ML, Jabs DA, Duncan JL, Srivastava SK

Adaptive optics retinal imaging: emerging clinical applications.

Optometry and vision science : official publication of the American Academy of Optometry

Godara P, Dubis AM, Roorda A, Duncan JL, Carroll J

Heterogeneous patterns of tissue injury in NARP syndrome.

Journal of neurology

Gelfand JM, Duncan JL, Racine CA, Gillum LA, Chin CT, Zhang Y, Zhang Q, Wong LJ, Roorda A, Green AJ

Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population.

Journal of medical genetics

Billingsley G, Bin J, Fieggen KJ, Duncan JL, Gerth C, Ogata K, Wodak SS, Traboulsi EI, Fishman GA, Paterson A, Chitayat D, Knueppel T, Millán JM, Mitchell GA, Deveault C, Héon E

Intense cyclic light-induced retinal degeneration in rats.

Archives of ophthalmology (Chicago, Ill. : 1960)

Duncan JL, LaVail MM

Retinal vascular abnormalities and dragged maculae in a carrier with a new NDP mutation (c.268delC) that caused severe Norrie disease in the proband.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Lin P, Shankar SP, Duncan J, Slavotinek A, Stone EM, Rutar T

Advances in imaging of Stargardt disease.

Advances in experimental medicine and biology

Chen Y, Roorda A, Duncan JL

Phenotypic variability due to a novel Glu292Lys variation in exon 8 of the BEST1 gene causing best macular dystrophy.

Archives of ophthalmology (Chicago, Ill. : 1960)

Sohn EH, Francis PJ, Duncan JL, Weleber RG, Saperstein DA, Farrell DF, Stone EM

Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations.

The Journal of comparative neurology

Lavail MM, Nishikawa S, Duncan JL, Yang H, Matthes MT, Yasumura D, Vollrath D, Overbeek PA, Ash JD, Robinson ML

Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation.

Investigative ophthalmology & visual science

Yoon MK, Roorda A, Zhang Y, Nakanishi C, Wong LJ, Zhang Q, Gillum L, Green A, Duncan JL

Retinal TrkB receptors regulate neural development in the inner, but not outer, retina.

Molecular and cellular neurosciences

Grishanin RN, Yang H, Liu X, Donohue-Rolfe K, Nune GC, Zang K, Xu B, Duncan JL, Lavail MM, Copenhagen DR, Reichardt LF

Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.

Investigative ophthalmology & visual science

McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan JL, LaVail MM

Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium.

Human gene therapy

Paskowitz DM, Greenberg KP, Yasumura D, Grimm D, Yang H, Duncan JL, Kay MA, Lavail MM, Flannery JG, Vollrath D

Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR

High-resolution imaging with adaptive optics in patients with inherited retinal degeneration.

Investigative ophthalmology & visual science

Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KE, Swaroop A, Roorda A

High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease.

Investigative ophthalmology & visual science

Roorda A, Zhang Y, Duncan JL

Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa.

Investigative ophthalmology & visual science

Rhee KD, Ruiz A, Duncan JL, Hauswirth WW, Lavail MM, Bok D, Yang XJ

Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy.

Investigative ophthalmology & visual science

Paskowitz DM, Donohue-Rolfe KM, Yang H, Yasumura D, Matthes MT, Hosseini K, Graybeal CM, Nune G, Zarbin MA, Lavail MM, Duncan JL

Factors affecting attrition in a longitudinal study of patients with AIDS.

AIDS care

Brown DM, Thorne JE, Foster GL, Duncan JL, Brune LM, Muñana A, Meinert CL, Jabs DA

Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Duncan JL, Yang H, Doan T, Silverstein RS, Murphy GJ, Nune G, Liu X, Copenhagen D, Tempel BL, Rieke F, Krizaj D

Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis.

American journal of ophthalmology

Acharya N, Lietman T, Cevallos V, Whitcher JP, Saidel M, Stone D, Duncan J, Margolis TP

Preface.

International Ophthalmology Clinics

Jacque L. Duncan, James Palmer

Retinal damage caused by photodynamic therapy can be reduced using BDNF.

Advances in experimental medicine and biology

Duncan JL, Paskowitz DM, Nune GC, Yasumura D, Yang H, Matthes MT, Zarbin MA, LaVail MM

Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation.

American journal of ophthalmology

Vagefi MR, Kim ET, Alvarado RG, Duncan JL, Howes EL, Crawford JB

Macular schisis detachment associated with angle-closure glaucoma.

Archives of ophthalmology (Chicago, Ill. : 1960)

Hollander DA, Barricks ME, Duncan JL, Irvine AR

Acute zonal occult outer retinopathy in a patient with graft-versus-host disease.

American journal of ophthalmology

Cheung MC, Nune GC, Hwang DG, Sutter EE, Duncan JL

Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.

Human molecular genetics

Kuo YM, Duncan JL, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J

BDNF reduces the retinal toxicity of verteporfin photodynamic therapy.

Investigative ophthalmology & visual science

Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL

Detection of localized retinal dysfunction in a choroideremia carrier.

American journal of ophthalmology

Cheung MC, Nune GC, Wang M, McTaggart KE, MacDonald IM, Duncan JL

An RCS-like retinal dystrophy phenotype in mer knockout mice.

Investigative ophthalmology & visual science

Duncan JL, LaVail MM, Yasumura D, Matthes MT, Yang H, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, Vollrath D

Macular Degeneration, Age Related.

Jacque L Duncan, Jeffrey W Berger, Stuart L Fine

Inherited retinal dystrophy in Mer knockout mice.

Advances in experimental medicine and biology

Duncan JL, Yang H, Vollrath D, Yasumura D, Matthes MT, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, LaVail MM

Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation.

Experimental eye research

Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV, Zolutukhin S, Hauswirth W, LaVail MM

Macular pigment and lutein supplementation in choroideremia.

Experimental eye research

Duncan JL, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG, Jacobson SG

Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.

Proceedings of the National Academy of Sciences of the United States of America

Vollrath D, Feng W, Duncan JL, Yasumura D, D'Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM

Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome.

Investigative ophthalmology & visual science

Aleman TS, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG

Linear nevus sebaceous syndrome: Authors’ reply.

Ophthalmology

Jacque L Duncan,Emmett T Cunningham